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Oxidative stress and micronutrient depletion may contribute to disease severity

Rodent Studies The following 15 studies were conducted on rodents and have been classified as follows: [25,26,27,28,29,30,31,32,33,34,35,36,37,38,39] Three studies analyzed the effects of semaglutide on ischemic stroke [25,29,35]

In summary, in-vivo and explant models of animals are well capable to study posttraumatic disc degeneration after major trauma or repeated trauma but are not well suited to study the long-term consequences after minor trauma due to different spinal loads and different healing capacities