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Kidney or liver issues : Dose adjustments or avoidance if severe, as the drugs are processed through these organs

For instance, in a study with BD patients, the administration of the TNF- inhibitor infliximab did not report either clinical improvement after its use or significant differences in gut microbiota composition [340]

A consistently higher dosage may result in adverse reactions like diarrhea, heartburn, upset stomach, and convulsions

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