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Semaglutide and tirzepatide create the caloric deficit by suppressing appetite, while lipotropics support hepatic fat clearance during that deficit

Additionally, GLP-1 agonists such as dulaglutide, semaglutide and liraglutide have been shown to provide cardiovascular benefits

3, Set 1978, pp

But the same 2025 review that catalogs those effects also underscores that only three human clinical trials have been published and that the compound remains investigational, with regulators having flagged it precisely because human safety and efficacy are not established