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Patients who received GLP-1 RA therapy (HR = 0.61
Heart-rate changes can have multiple causes and do not identify one receptor
Similar associations have been reported in bipolar disorder and systemic lupus erythematosus, where individuals with severe BBB disruption had more extensive brain volume loss or greater psychiatric morbidity 50,51
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In these scenarios, a higher-dose B12 supplement (typically 502,000 micrograms daily) or prescribed treatment may be necessary to restore and maintain adequate levels
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