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Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

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Acetate and acetylation Acetyl-CoA, as an important intermediate product in carbon metabolism, can participate in the TCA cycle, lipid and steroid synthesis, protein acetylation, and many other biological processes, thereby regulating energy generation, cell proliferation, gene transcription, etc

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Combined with GLP-1 medications that reduce fluid intake through appetite suppression, the result can be significant dehydration that manifests as severe dry mouth, lightheadedness , and leg cramps