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3 were initially assigned a role in maintaining GSH homeostasis ( Arabidopsis , mirroring the function of mammalian CHAC2 (Ito and Ohkama-Ohtsu, 2023)

Finkielstein VA, Goldfarb DS

This reactive transformation entails morphological, functional and transcriptional remodeling, forming a continuum of activation states ranging from transient, protective responses to chronic, neurotoxic phenotypes

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Changes in Levels of the Antioxidant Glutathione in Brain and Blood Across the Age Span of Healthy Adults: A Systematic Review. NeuroImage: Clinical 40: 103503