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Long-term conclusions rely on extrapolation Marie Spreckley, obesity researcher and public health nutritionist at the University of Cambridge in England, who was not involved in the study, cautioned that the papers long-term conclusions rely on modeled projections, rather than observed data, as the follow-up period for stopping treatment with newer medicines is limited to about 12 months

In the STEP TEENS trial, nearly three-quarters of participants improved their BMI category by at least one level, and over 40% reached a BMI below the obesity threshold ( Safety data in youth are generally reassuring but incomplete

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Fatigue: Some users report mild tiredness or lethargy in the hours following administration