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In a previous study in a mouse model of Alzheimers disease, Tirzepatide did not show any protective effects and did not reduce inflammation in the brain either (61)

Tirzepatide patients lost an average of 1.1% more lean body mass after three months and 2% after 12 months of continuous use, the analysis by Massachusetts-based data analytics firm nference found

They may not achieve adequate glycemic control or lose weight as expected

For Study 3, the primary efficacy parameters were mean percent change in body weight from randomization (Week 0) to Week 72 and the percentage of patients achieving 5% weight reduction from randomization (Week 0) to Week 72