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PIONEER 3 PIONEER 3 compared the efficacy and safety of the addition of oral semaglutide or the DPP-4 inhibitor sitagliptin as add-on therapy in patients with T2DM receiving metformin with or without a sulfonylurea

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Insulin is a key hormone involved in blood glucose regulation, facilitating glucose uptake and utilization in muscles and adipose tissue 43,44

can reduce mast cell degranulation and T-cell activation in LPS-stimulated RAW 264.7 macrophages by inhibiting Orai-1 and TRPV3 channels, which can impact pruritus and inflammation in eczematous conditions ( T