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In general, VPA-poisoned patients are managed with supportive care alone and gastrointestinal decontamination, if appropriate [6]

Edaravone, a free-radical scavenger approved in Japan for acute ischemic stroke, has demonstrated protective effects in tourniquet- induced muscle I/R in murine models but is not approved for limb I/R indications outside Japan.38 Mitochondrial permeability transition pore inhibitors reduce skeletal muscle and renal injury in rat lower-limb I/R models but are limited in clinical translation due to immunosuppressive and pharmacokinetic constraints.39 Nitric oxide donors and L-arginine improve microvascular perfusion, enhance endothelial function, and reduce oxidative stress

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Emerging evidence suggests they may also influence neurobiological processes that contribute to addictive behaviors