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There are many contradictory findings made in the literature, including the fact that APR-246, as a conformationally stabilizing compound, should primarily affect conformational p53 mutants

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Schatz SB, Jngst C, Keitel-Anselmo V, Kubitz R, Becker C, Gerner P, Pfister ED, Goldschmidt I, Junge N, Wenning D, et al