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Electrophysiological recordings support this notion and have demonstrated that GLP-1 directly stimulates POMC/CART cells, whereas GLP-1 can also inhibit orexigenic NPY/AgRP cells in the ARC through an indirect mechanism (Secher et al., 2014)

The NAc, which is part of the ventral striatum, plays a pivotal role in addiction and relapse [126, 127, 128]

Studies show liraglutide delays gastric emptying at five and 16 weeks of treatment

Stephenson JTC, Harris K

Clinical trials show impressive results: tirzepatide reduced the apnea-hypopnea index (AHI) by up to 63% approximately 30 fewer breathing interruptions per hour 33