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[4] [11] This mechanism becomes clinically relevant when treating pernicious anaemia or intrinsic factor deficiency with high-dose oral supplementation

In the first stage, each model was constrained to obtain an optimal fit to the gene expression signature of the cell line by solving a Mixed Integer Linear Programming problem, via the integrative Metabolic Analysis Tool (iMAT) 32,33

no Phase 2 or Phase 3 human safety trials have been completed

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