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On an empty stomach immediately upon waking

Appetite starts shifting gently

Why this may happen: A high BMI is one lifestyle factor that can make it harder to get pregnant

Contact your GP or prescribing clinician if you experience cold intolerance accompanied by other symptoms that might suggest thyroid dysfunction, such as: Extreme fatigue or weakness that interferes with daily activities Unexplained weight gain or cessation of weight loss despite adherence to treatment Significant hair loss or changes in hair texture Persistent constipation unresponsive to usual measures Dry, flaky skin or changes in skin texture Muscle aches, cramps, or weakness Slowed heart rate Depression or significant mood changes Cognitive difficulties, including memory problems or difficulty concentrating These symptoms could indicate hypothyroidism , which requires investigation through thyroid function tests (TSH, free T4)

The METAOD006 (OPTIONS) oral Phase 2b trial measured weight at 12 and 24 weeks