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For 80%-90% of people with systemic mastocytosis, a mutation in the KIT gene is the cause

Current practice converges around three tiers: The split-dose protocol (250 mcg morning, 250 mcg 3+ hours post-meal in the evening) creates two daily windows of lipolytic stimulation

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Regarding the form of vitamin B12 used, cyanocobalamin was the most common (n = 14), followed by methylcobalamin (n = 6), hydroxocobalamin (n = 4), and combinations including adenosylcobalamin in isolated cases