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Adults on GLP-1 receptor agonists for extended periods show reduced risk of cognitive decline and dementia in several observational and trial datasets, with effect sizes ranging from modest single-digit reductions to much larger ones, depending on the cohort

Obesity and chronic diseases like type 2 diabetes can contribute to a range of mental health problems, including depression, anxiety, and poor self-esteem

On the other hand, PPIs that have evolved to overcome the drawbacks of covalent modifiers lack bioavailability and are currently not applicable for the treatment of neurological disorders

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