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That trial enrolled 338 adults with obesity or overweight without type 2 diabetes, randomized across placebo and four retatrutide dose levels (1 mg, 4 mg, 8 mg, 12 mg weekly), and followed participants for 24 weeks
The molecule that emerged from this foundational work carried a disabling flaw as a therapeutic scaffold: native GLP-1 is degraded almost immediately by the serine protease dipeptidyl peptidase-4 (DPP-4), which cleaves the peptide between residues 8 and 9 and confers a circulating half-life of under two minutes [4]
10 This reduction in diabetes risk is crucial since T2D is associated with an increased risk of heart disease and other cardiometabolic complications
This reduces food cravings and hunger pangs
Outcomes 10 , 366378 (2024)
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