These effects are largely mediated through activation of Wnt/-catenin, BMP2/Smad/Runx2, PI3K/Akt, MAPK, and GLP-1Rdependent cascades, supporting their potential as multifunctional modulators in regenerative medicine (Fig
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Since insulin therapy often indicates more advanced disease progression, greater severity, or additional comorbidities, which may lead to a higher risk of intestinal obstruction, and there was no statistically significant difference in intestinal obstruction risk between GLP-1RAs and other anti-diabetic medications (e.g., SGLT2 inhibitors, metformin, sulfonylureas, thiazolidinediones, DPP-4 inhibitors), the observed reduction relative to insulin does not necessarily suggest a protective effect of GLP-1RAs against intestinal obstruction
