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Copper(II) ions serve as essential cofactors for numerous enzymes involved in tissue repair, including lysyl oxidase (collagen cross-linking), cytochrome c oxidase (mitochondrial energy production), and superoxide dismutase (antioxidant defense)

Some of the coenzyme Q derivatives, such as idebenone or vatiquinone (EPI-743), have been tested with various models and even subjected to human clinical trials of neurodegenerative diseases, and they seem to have only limited benefit (Zesiewicz et al., 2018)

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