Subsequently, Western Blot (WB) analysis detected a decrease in total P53 expression but an increase in phosphorylated P53 (p-P53) expression in OGD-induced senescent endothelial cells post FOXO4-DRI treatment (Figures 5B,C)
Additionally, the quantity of proinflammatory cytokines is directly correlated with the accumulation of A plaques in AD, partly due to reduced A clearance as well as increased astrocytic A production [147, 148]
[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Nauck M.A., Meier J.J
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