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Oxidative Stress, Copper, and Glutathione Regulation of Copper Transport and Cell Viability During Copper Metabolism Copper (Cu) is an essential cofactor in virtually all organisms, and tight control of Cu metabolic pathways are critical for optimal cellular viability

This is depicted in a typical original experiment in Fig

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Neuroinflammation, characterized by the appearance of reactive astrocytes and microglia as well as macrophage and T-lymphocyte infiltration, appears to be highly involved in the disease pathogenesis, highlighting the involvement of non-neuronal cells in neurodegeneration