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In the current study, depriving RPE cells of the essential GSH precursor Cys 2 by culturing cells in Cys 2 -free culture medium or blocking de novo synthesis of GSH by using GCL inhibitor BSO or blocking Cys 2 uptake by pharmaceutical inhibition of system x c caused cell death
They found that, at the beginning of the aggregation process, nearly all of Abeta-40s amides had access to free exchange, whereas only about 33 of the 41 amides available in Abeta-42 underwent exchange
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