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MIP-1 expression induced by co-stimulation of human monocytic cells with palmitate and TNF- involves the TLR4-IRF3 pathway and is amplified by oxidative stress

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Interestingly, concomitant increases in metabolites related to methylated and oxidized waste products of nicotinamide were also observed in PBMCs, especially MeNAM, N -methyl-2-pyridone-5-carboxamide (Me2PY), and N -methyl-4-pyridone-5-carboxamide (Me4PY) [76] (Table 2)