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Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles

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In a double-blind, placebo-controlled, dose-titration study, 1 to 3 g/day of oral propionyl-L-carnitine for 24 weeks was well tolerated and improved maximal walking distance in patients with intermittent claudication (64)

Lean mass and lipids Trials and meta-analyses report increases in lean body mass and improvements in selected lipid measures, while effects on glucose vary by baseline risk and treatment response