However, this delicate balance can be perturbed by an imbalance in the quantity of one or multiple components, potentially leading to dysfunction of the thyroid gland and a heightened susceptibility to autoimmune thyroid disorders (24, 25)
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Other metals which are present in the environment as industrial pollutants are not able to generate free radicals by shuttling between contiguous oxidation states but it is known that organisms exposed either in their natural environment or in toxicological experiments show signs of oxidative stress, and some metals, such as As, Cd and Hg, are also carcinogenic to humans
Role of impaired Nrf2 activation in the pathogenesis of oxidative stress and inflammation in chronic tubulo-interstitial nephropathy