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At minimum: IGF-1 every 4 weeks, fasting glucose and insulin every 2 weeks initially (monthly once stable), HbA1c every 6 weeks, liver enzymes monthly, and comprehensive metabolic panel quarterly

T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice

In case of infections, pathogenic cells are eliminated by antigen-specific therapies, utilizing existing autoantigens like heat shock proteins, and their derived peptides, leaving the immune system of the body unaffected (Cabrales-Rico et al