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Although cortisol itself has anti-inflammatory effects, prolonged high levels of cortisol may induce glucocorticoid resistance, which in turn downregulates GC receptor-mediated transcriptional activity, diminishing its anti-inflammatory efficacy and exacerbating the inflammatory response (120)

A lot of trials examine secondary changes, like reduced blood pressure or improved glucose regulation, which typically begin to emerge at the six-month mark

Gastrointestinal Disorders: Conditions like celiac disease, Crohns disease, or irritable bowel syndrome (IBS) can affect how the body absorbs nutrients like iron, vitamin B12, and folate

History of pancreatitis or gallbladder disease, because these conditions may worsen with GLP-1 medications

especially relevant for longer protocols Lipid panel: GH influences HDL, LDL, and triglyceride metabolism