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Patients experiencing persistent fatigue or malaise should ensure adequate caloric intake despite reduced appetite, as excessive caloric restriction can worsen systemic symptoms

Underlying factors Fatigue can result from other factors unrelated to semaglutide, such as stress, lack of sleep, or an underlying medical condition

This is a medication that works by influencing appetite and digestion, and as your body adjusts, certain symptoms can occur especially in the first few weeks

This dual mechanism supports appetite control and improved insulin response, offering a broader range of benefits compared to single-action GLP-1 medications