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AHK-Cu, or Alanine-Histidine-Lysine-Copper, is a naturally occurring tripeptide complexed with copper that has been investigated for its role in activating copper-dependent enzymatic processes and modulating extracellular matrix proteins involved in tissue structure and repair

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It also shows unique protective effects on the gastrointestinal system, which is why oral administration remains viable for gut-related applications

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Rubenstein JH, Inadomi JM, Scheiman J, Schoenfeld P, Appelman H, Zhang M, Metko V, Kao JY (2014) Association between Helicobacter pylori and Barrett's esophagus, erosive esophagitis, and gastroesophageal reflux symptoms