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Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis
doi: 10.3390/ijms17050733
Does taking PEA (palmitoylethanolamide) reduce migraine pain or lessen the number and severity of future episodes
systemic mechanisms Relevant for gastrointestinal disease models Mimics natural exposure route for gastric-derived peptide Research Convenience: Simpler administration protocols in research settings Reduced training requirements for research staff Fewer regulatory restrictions compared to injectable protocols Enables self-administration paradigms in appropriate models Pharmaceutical Development Relevance: Oral formulations represent preferred route for most therapeutics Research informs commercial drug development potential Investigation of druggability principles for oral peptides Patent and intellectual property opportunities in formulation science Limitations and Research Considerations: Variable Bioavailability: Lower and more variable bioavailability vs
This work reveals a strategy to fine-tune growth-defense balance in chloroplasts by manipulating MORF2, and a pathogenic strategy to subvert the process and promote infection via enzymatically nonfunctional effector stabilizing MORF2
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