However, for individuals actively managing complex, reactive chronic illnesses like Long COVID, ME/CFS, or severe dysautonomia, such high starting doses are rarely recommended due to the high potential for gastrointestinal upset or rapid, uncomfortable detoxification reactions (often referred to as a Herxheimer reaction)
Orally Gastrointestinal discomfort, allergic reactions, worsening of asthma, toxicity, and interference with other medications
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Vijiaratnam N, Girges C, Auld G, Chau M, Maclagan K, King A, et al
One proposed function of sleep may be the mitigation of oxidative stress in both brain and peripheral tissues, contributing to the clearance of reactive species that accumulate during wakefulness