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The With No Lysine Kinase 1 (WNK1) kinase inhibitor WNK463 regulates right ventricular glucose metabolism by inhibiting GLUT1/4 expression and protein glycosylation, while affecting mitochondrial fatty acid oxidation pathways, thereby improving metabolic disorders and alleviating right ventricular dysfunction

Excessive ROS can also alter and degrade extracellular matrix proteins and impair the function of keratinocytes and fibroblasts 162

While the immune system reacts abnormally to progesterone, many symptoms are driven by mast cell activation and histamine release rather than classic autoantibodies, which is why antihistamines are often effective

Although ADT is effective, the metabolic reprogramming it induces drives CRPC development

Rangel Rivera, G