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Subsequent trials (STEP 2 through STEP 8) confirmed these findings across diverse patient populations, highlighting the critical role of maintaining therapeutic doses (1.7 mg and 2.4 mg) to sustain weight loss and prevent weight regain

Plasticity and protein synthesis : Several animal models of autism, including mice with a mutation in the SHANK3 gene, show disruptions in a form of synaptic plasticity called homeostatic scaling, which allows neurons to maintain a steady firing rate despite shifts in their overall excitability