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421 Research, primarily using experimental models of mechanical nerve damage, has explored the mechanisms underlying neuropathic pain, revealing increased excitation and facilitation of pain signals, along with a loss of inhibition in both the PNS and the CNS

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The GCH1-BH4 axis reduces the risk of lipid peroxidation by depleting ROS, controlling BH4 synthesis, and reducing the oxidized state CoQ to CoQH2 in cells

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