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Research which looked at the genetics of nearly 28,000 people taking a GLP-1 drug also identified genetic issues in another set of receptor genes called GLP-1R and GIPR

Their study also showed that nearly 40% of GLP-1 users experience gastrointestinal side effects nausea, vomiting, diarrhea, constipation, and altered appetite and satiety regulation

162,163 In a randomized placebo-controlled trial in 100 women with menopausal symptoms, treatment with a traditional formulation of dong quai plus astragalus for six months led to a significant reduction in mild hot flashes, but no other improvements in menopausal symptoms, relative to placebo