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Isolation of rat heart mitochondria Upon cervical dislocation of 912 weeks old male Wistar rats (Charles River, UK), heart mitochondria (RHM) were prepared by homogenization of their heart tissue in STEB buffer (250 mM sucrose, 5 mM Tris-HCl and 1 mM EGTA, pH 7.4) supplemented with 0.1% fatty acidfree BSA

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Patients who failed to meet specific glycemic goals during the trial were treated with glipizide (or other sulfonylurea) rescue

Also spending heavily on ADCs was AbbVie, with its late-November $10 billion acquisition of ImmunoGen, whose portfolio includes ovarian cancer drug Elahere (mirvetuximab soravtansine)