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Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss

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There are benefits I dont necessarily see but believe in like oxidative stress protection

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Cognitive function did not decline in either group over the two-year period (175), suggesting that longer intervention trials are needed to determine whether long-chain omega-3 fatty acids have utility in the prevention of age-related cognitive decline