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According to Robert Kushner, an obesity researcher at Northwestern University Feinberg School of Medicine , who led one of the STEP studies, semaglutide is a "game-changer" for people with obesity

This receptor population may account for the rapid and sustained, but relatively small, increase in pulse rate with GLP-1RAs in humans (100, 101)

However, the magnitude of effect differs proportionally, and consumers must calibrate expectations accordingly

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