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These are manufactured by the original pharmaceutical companies, have gone through the full FDA approval process, and are sold at set prices

The hazard-ratios [95% CI] of the composite kidney outcome with GLP-1 RAs versus basal insulin were 0.96 [0.821.11] (p = 0.566) and 0.71 [0.540.95] (p = 0.020) in the ITT and AT analyses, respectively

J Clin Invest 122: 388-402, 2012

"I think this still is going to have a significant role." The results of a phase 3 clinical trial found orforglipron delivered "significant weight loss" compared to a placebo in adults with obesity or overweight and Type 2 diabetes, and a "meaningful" reduction in A1C (a test used to measure blood sugar levels), Eli Lilly noted in a statement