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That said, there are biologically plausible indirect pathways by which semaglutide treatmentespecially when accompanied by rapid appetite suppression, gastrointestinal adverse effects, and clinically meaningful weight losscould unmask or exacerbate pre-existing vaginal symptoms (for example, genitourinary syndrome of menopause) or contribute to discomfort through dehydration, altered sex steroid milieu, or pelvic soft-tissue volume changes

International Journal of Molecular Sciences

Am J Physiol-Endocrinol Metab

Mechanistically, we demonstrated that Sema exerts its regulatory effect on myocardial energy metabolism via the regulation of Creb5/NR4a1 in vitro and in vivo

Stop plan: what glucose changes should prompt follow-up