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Consequently, the regulation of mitochondrial function over the course of ASD pathogenesis and pathophysiology may be intimately linked to alterations in the interactions of the serotonergic and melatonergic pathways

These include immune-mediated cytokine release, hormonal modulation through the hypothalamicpituitaryadrenal (HPA) axis, and neural pathways involving both the enteric nervous system (ENS) and the vagus nerve (Guzzetta et al., 2022

While the 28-day treatment period and use of only male rats were consistent with standard protocols to reduce variability in early-phase toxicological studies, these choices limit the extrapolation of our findings to chronic exposure scenarios and across sexes

While you can technically stop tirzepatide immediately without physical harm from withdrawal, the metabolic and weight-related consequences of stopping require careful consideration and planning

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