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However, under pathological conditions, activated MMPs are associated with increased degradation of ECM components and are involved in ECM re-modeling (Dollery et al., 40 oligomers can increase MMP-2 activity in stimulated astrocytes and correlated with increased oxidative stress, inflammation and reduced cell viability

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Secondly, overexpression of GSH in TME clears ROS and weakens the performance of ferroptosis therapy (FT) in tumors