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A notable initiative addressing this gap is the targeting aging with metformin trial, which seeks to establish a regulatory precedent for aging as a treatable indication by employing a composite endpoint encompassing multiple age-related diseases 124

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M., Leech, J., Murphy, C., DeBros, G., Budson, A., & Solomon, P

When compared to the age- and sex-matched healthy controls, the patients with depression had substantially lower levels of acetyl-L-carnitine