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By modifying the primary sequence of OXM and linking to the constant region of human IgG4, Jung and colleagues demonstrated their peptide HM12525A had a potent and balanced activity at both GLP-1 and glucagon receptors in vitro and led to body weight loss of 30% in DIO mice over 14 days compared to liraglutide treated mice (74)

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Long-term data beyond a few years is still being collected, and doctors continue to monitor for rarer risks as more people stay on these medications for longer periods

No, hasta ahora no se ha demostrado que su eficacia aumente al disminuir las dosis temporalmente