Conventional thinking posits that a primary defect in adaptive immunity promotes recruitment and entry of peripherally activated lymphocytes into the CNS across a disrupted bloodbrain barrier where a complex cascade of autoimmune/inflammatory processes culminates in edema, and destruction of myelin, axons and oligodendrocytes (for detailed reviews see Dendrou et al., 2015
As a mucolytic agent, NAC (N-Acetylcysteine) reduces the viscosity of mucus, aiding in clearing the sinuses and reducing obstruction
The 30-day cycle is designed with a margin for occasional missed days
Published mechanisms include upregulation of growth hormone receptor expression, promotion of angiogenesis via VEGF pathway activation, modulation of the nitric oxide system, and interaction with the dopaminergic and serotonergic systems in neurological models
Briefly, TM3 cells were seeded into 96-well plates at a density of 510 3 cells/well