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The broader 2026 context matters: as of May 2026, the FDA has proposed regulatory changes affecting compounded semaglutide and tirzepatide, with a public comment period closing June 29, 2026

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This interplay between iron metabolism and hypoxia is particularly significant in the context of CSCs, which reside in hypoxic niches [91] and leverage these adaptive responses to sustain their stemness properties and resistance to therapeutics (reviewed [92])

doi: 10.1016/S2213-8587(21)00019-X 10 American Diabetes Association Professional Practice Committee

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