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December 1, 2010

Davies MJ, Aronne LJ, Caterson ID, Thomsen AB, Jacobsen PB, Marso SP, et al

The molecular design principles that enable this extended half-lifeincluding the C18 fatty acid chain, which confers strong albumin binding, and amino acid substitutions that confer DPP-4 resistancewere elucidated during the development of semaglutide (Lau et al., 2015)

Retinoid precursors, such as retinol (vitamin A) and retinaldehyde, which need to be metabolically converted into the active form of retinoic acid, are more often used in cosmeceuticals, but have lower potency than retinoic acid [66, 144, 146, 147]

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