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Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S

They share the same ultimate goal,supporting GH output, but do so through different mechanisms and with different pharmacokinetic profiles

( A C ) TNBC metastatic 4T07 and 4T1 ( A ), D2A1-m1 and D2A1-m2 ( B ), human MDA-MB-468 and MDA-MB-231 ( C ) cells were pre-treated with 10 M FADS2i (SC-26196), FADS1/2i (CP-24879), and SCD1i (CAY10566) for 4 h, exposed ON to 0.5 M erastin, and subjected to cell viability assay ( n = 3 biological replicates in either single, duplicate or technical triplicate)

Thanks, Jessie

Jiang, C