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However, no difference was found between the two groups when comparing changes in total glutathione levels (responders p = 0.05, non-responders p = 0.06) (Table 4)

Further optimization of the timing, dose, and duration of IGF-1R mAb treatment is warranted in order to maximize benefits while minimizing risks, particularly given recent evidence that transient administration of other drugs can have persistent benefits on age-related outcomes 43