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Challenging reimbursement processes in countries may also lead to nonadherence [78]

14 In contrast, studies report that administering GABA-A receptor antagonists to rodents in the striatum and intra-cortex induces twitching symptoms, which can be alleviated by the administration of GABA-A receptor agonists

Tailoring the dosage to the patient's unique characteristics helps optimize treatment efficacy while minimizing the risk of adverse effects

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453 However, a subsequent phase 2 clinical trial (NCT04129944) failed to demonstrate the efficacy of single-dose, intra-articular dosing of UBX0101 in patients with painful knee osteoarthritis